منابع مشابه
Inferring Gene Family Histories in Yeast Identifies Lineage Specific Expansions
The complement of genes found in the genome is a balance between gene gain and gene loss. Knowledge of the specific genes that are gained and lost over evolutionary time allows an understanding of the evolution of biological functions. Here we use new evolutionary models to infer gene family histories across complete yeast genomes; these models allow us to estimate the relative genome-wide rate...
متن کاملObtaining family histories from patients with cancer.
Information obtained from family history data can provide valuable insight into the biologic and environmental etiologies of an individual's personal and family history of disease. The purpose of this article is to provide a brief introduction to cancer genetics and discuss ways to obtain accurate family histories in a time-efficient manner to identify families with a hereditary cancer syndrome...
متن کاملThe Construction and Interrogation of Actor Based Simulation Histories
Large socio-technical systems are complex to comprehend in their entirety because information exchanges between system components lend an emergent nature to the overall system behaviour. Although Individual system component behaviour may be known at the outset, such components may exhibit uncertainty and further exacerbate issues of a priori prediction of the overall system behaviour. Multi-age...
متن کاملGene Family: Structure, Organization and Evolution
Gene families are considered as groups of homologous genes which they share very similar sequences and they may have identical functions. Members of gene families may be found in tandem repeats or interspersed through the genome. These sequences are copies of the ancestral genes which have underwent changes. The multiple copies of each gene in a family were constructed based on gene duplicati...
متن کاملReconstructing Histories of Complex Gene Clusters on a Phylogeny
Clusters of genes that have evolved by repeated segmental duplication present difficult challenges throughout genomic analysis, from sequence assembly to functional analysis. These clusters are one of the major sources of evolutionary innovation, and they are linked to multiple diseases, including HIV and a variety of cancers. Understanding their evolutionary histories is a key to the applicati...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2014
ISSN: 1471-2105
DOI: 10.1186/1471-2105-15-s3-a8